Thus, always check with your own physician and pharmacist to verify before starting any natural supplement. They specialize in natural remedies and compounding for both human and veterinarian use, as well as lifestyle modification, including Ideal Protein. They would love to hear from you! Check them out at www. Everything mentioned in their article is available InStore. Get all the specials, weekly sales, deals and offers from Canada's community pharmacy. As a source of this amino acid, DLPA might have the same effects, but no studies have confirmed this yet.
D-phenylalanine — the other half of DLPA — raises the levels of our internal opioids. This led researchers to investigate its painkiller effects, but the results from clinical trials were discouraging [ 19 , 25 , 26 , 27 ]. Some doctors have reported positive results in pain management with large doses 1,, mg daily of DLPA.
According to them, antidepressant and painkiller effects of DLPA are tightly linked. Bottom line? Low dopamine is one of the triggers of ADHD.
In theory, phenylalanine may help with ADHD and other attention disorders by supplying dopamine [ 29 ]. In one older analysis, 44 children with ADHD had lower blood and urine phenylalanine levels than their healthy peers. But according to a more recent study, children with ADHD have normal phenylalanine levels [ 30 , 31 ]. However, 3 months after the study finished, the beneficial effects disappeared [ 32 ].
D-phenylalanine had no beneficial effects on 19 hyperactive boys in another study. A review of clinical trials found no significant benefits of phenylalanine for ADHD [ 33 , 34 ]. This list does not cover all possible side effects. Contact your doctor or pharmacist if you notice any other side effects. In Canada, you may report side effects to Health Canada at Clinical trials reported no significant DLPA side effects [ 17 , 16 , 15 , 32 ].
L- and D-phenylalanine as single supplements are also safe and well-tolerated [ 10 , 34 ]. The same might go for DLPA [ 22 , 35 ]. People with a rare metabolic disorder — phenylketonuria PKU — are unable to process phenylalanine properly. The accumulation of this amino acid can cause brain damage and cognitive impairment in PKU patients [ 36 , 37 , 38 ].
These people follow a special low-protein diet to minimize the intake of phenylalanine. Obviously, they should steer clear of DLPA other phenylalanine supplement s [ 39 , 40 ].
Supplement-drug interactions can be dangerous and, in rare cases, even life-threatening. Always consult your doctor before supplementing and let him know about all drugs and supplements you are using or considering. DLPA might not have the same effects, but caution is warranted. Speak with your doctor before supplementing. Most supplements contain pills with , mg of DLPA. Some research suggests that people with tardive dyskinesia may process phenylalanine abnormally.
Until more is known, it makes sense for people with this condition to avoid phenylalanine supplementation. LPA competes with several other amino acids for uptake into the body and the brain. Therefore, for best results, phenylalanine should be taken between meals, or away from protein-containing foods. People taking prescription or over-the-counter medications should consult a physician before taking DLPA.
The maximum amount of DLPA that is safe is unknown. However, consistent toxicity in healthy people has not been reported with 1, mg per day or less of DLPA, except for occasional nausea, heartburn , or transient headaches. When mg of LPA per 2. Although no serious adverse effects have been reported in humans taking phenylalanine, amounts greater than 1, mg per day should be supervised by a doctor.
Phenylalanine with UVA for the treatment of vitiligo needs more testing for possible side effects. J Am Acad Dermatol ; [letter]. Learn more about TraceGains, the company. The information presented by TraceGains is for informational purposes only. It is based on scientific studies human, animal, or in vitro , clinical experience, or traditional usage as cited in each article.
The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available.
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Uses L-phenylalanine LPA serves as a building block for the various proteins that are produced in the body. What Are Star Ratings? This supplement has been used in connection with the following health conditions: Used for Why 2 Stars. In one study, depressed people given L-phenylalanine experienced results comparable to those produced by an antidepressant. Several studies suggest that a synthetic version of phenylalanine called D-phenylalaline, may reduce pain by decreasing the enzyme that breaks down endorphins.
D-phenylalanine DPA decreases pain by blocking the enzymes that break down the body's natural painkillers. Clinical studies suggest DPA may inhibit some types of chronic pain. In one trial, D-phenylalanine DPA supplementation improved motor control and tremors in people with Parkinson's disease. L-phenylalanine, in conjunction with ultraviolet light exposure, may improve repigmentation of skin.
In double-blind research, alcoholics treated with L-tyrosine combined with DLPA D,L-phenylalanine , L-glutamine, prescription L-tryptophan, plus a multivitamin had reduced withdrawal symptoms and decreased stress.
In double-blind research, alcoholics treated with DLPA D,L-phenylalanine combined with L-tyrosine, L-glutamine, prescription L-tryptophan, plus a multivitamin had reduced withdrawal symptoms and decreased stress.
Supplementing with D-phenylalanine DPA has been shown to reduce chronic pain due to osteoarthritis. DPA inhibits the enzyme that breaks down some of the body's natural painkillers. D-phenylalanine has been used with mixed results to treat chronic pain, including pain caused by rheumatoid arthritis. Possible Deficiencies People whose diets are very low in protein may develop a deficiency of LPA, although this is believed to be very uncommon.
Interactions with Medicines As of the last update, we found no reported interactions between this supplement and medicines.
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